Ah, a good-old fashioned literary scandal. The Smoking Gun (and others) has questioned the veracity of James Frey's Oprah-canonized drug addiction memoir, "A Million Little Pieces."
I personally was never able to read it once I heard it included dare-you-to-read-it scenes like one in which he undergoes a root canal without anesthesia, so I can't comment on the books, but The Smoking Gun lays out what looks like an amazingly thorough case. Frey's non-response is here. There's also a Metafilter discussion here, and a hilarious book review here.